I have recently been reading this scripture over and over and over. Its a great battle between "Foolishness" and "Worldly Wisdom." This is a great chunk of scripture that empowers those of us that may feel like the "underdogs" when it comes to living for Christ. I would recommend reading this passage at least 4 times to get it to soak in, and don't forget to circle the word "fool" as you come across it.
If God is looking for fools to impact the world, then count me in.